New mouse model of tau propagation

Accumulation of assembled tau protein in the central nervous system is characteristic of Alzheimer’s disease and several other neurodegenerative diseases, called tauopathies. Recent studies have revealed that propagation of assembled tau is key to understanding the pathological mechanisms of these diseases. Mouse models of tau propagation are established by injecting human-derived tau seeds intracerebrally; nevertheless, […]

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Decreased protein degradation in cerebellum leads to motor dysfunction

A research team from Kumamoto University, Japan has developed an animal model that reproduces motor dysfunction and cerebellar neurodegeneration similar to that in spinocerebellar ataxia (SCA) by inhibiting chaperone-mediated autophagy (CMA) in cerebellar neurons. Since CMA activity is reduced in cells expressing SCA causing proteins, CMA is expected to become a new therapeutic target for […]

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Meditation for mind-control

Carnegie Mellon Biomedical Engineering Department Head Bin He and his team have discovered that mindful meditation can help subjects learn and improve the ability to mind-control brain computer interfaces (BCIs). A BCI is an apparatus that allows an individual to control a machine or computer directly from their brain. Non-invasive means of control like electroencephalogram […]

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Scientists identify dozens of genes allowing cancer cells to evade the immune system

Toronto scientists have mapped the genes allowing cancer cells to avoid getting killed by the immune system in a finding that paves the way for the development of immunotherapies that would be effective for larger patient populations and across different tumour types. “Over the last decade, different forms of immunotherapy have emerged as really potent […]

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